Washington State University College of Pharmacy

United States Transuranium & Uranium Registries

USTUR Provides Unique Resource for Testing Actinide Internal Dosimetry

IPP splash screenThe IMBA Expert™ USDOE-Edition (IX) software suite was developed (jointly in the US and UK – with partial DOE support), in order to standardize internal dose assessments at DOE sites.  The IMBA system is a series of independent, quality assured modules that implement the International Commission on Radiological Protection (ICRP) Publication 66, Human Respiratory Tract Model (HRTM) and the currently recommended ICRP biokinetic models.

In December, 2006, DOE added version 4.0.28 of this software to the Central Registry Toolbox, and also provided “Guidance on the Use of IMBA Software for Safety Applications” (DOE-HS-002).

In effect the IMBA software now provides DOE (and other US federal agencies) with a unified, practical, up-to-date methodology for assessing intakes and doses from bioassay data.  Furthermore, this methodology is also widely adopted internationally (list of current users).

The large USTUR human data resource is unique in providing absolute tests of how well this current (and still developing) methodology succeeds in predicting actinide uptake and retention (and thus tissue doses) from bioassay data of widely differing quality and scope.  Some USTUR cases have only sparse bioassay data (including measurements below the contemporary ‘limit of detection’), whereas others have abundant (positive) bioassay data in addition to USTUR’s measured tissue actinide contents.

The UK’s Health Protection Agency (HPA), ongoing developer and publisher of IMBA Professional Plus (IPP) – the successor of IMBA Expert™ USDOE-Edition – has granted USTUR a license to use IPP in our research program.  In return, USTUR helps the software development team at HPA test advanced new statistical and other ‘beta-development’ features of the software for potential incorporation in future software versions.

The IPP software also incorporates special calculations of annual tissue doses developed for IMBA Expert™ OCAS/ORAU-Edition to support reconstructions of internal dose carried out by CDC/NIOSH/OCAS under the Energy Employee’s Occupational Illness Program Act (EEOICPA, 2000).  You can download here electronic copies of the technical documentation for IMBA Expert™ OCAS/ORAU-Edition – with permission of the copyright holder (ACJ & Associates, Inc.):

» User Manual [5.5 Mb - pdf]
» Appendix A: Technical Basis [5.0 Mb - pdf]
» Appendix B: Bioassay Quality Assurance [5.6 Mb - pdf]
» Appendix C: Dose Quality Assurance [4.4 Mb - pdf]
» Appendix D: Example Cases [5.3 Mb - pdf]

The IPP software system shares with its predecessor IMBA Expert™ Editions a common data file format (nominally ‘parameters.ix’).  For example, the file '0855_Case.ix [zip]’ defines all of the model assumptions and bioassay data used by USTUR to assess Registrant #0855’s accidental 241AmO2 intake and resulting tissue doses.  Any licensed user of the IPP software, or any of its predecessors (including international users), can download this “*.ix” file – and repeat for themselves USTUR’s assessment – or carry out their own assessment. Full IPP case reports (i.e. 0855_Case.RPT.txt) detail input information and the results of calculations. See below 'IPP report form'.

On completion of each Registrant case study, USTUR will publish the primary “*.ix” file for download from http://www.ustur.wsu.edu/DeidentifiedData/Narratives.html.

Fully comprehensive case reports can be generated using the IPP report form.

This page was last updated on July 29, 2007. usturwebmaster@tricity.wsu.edu

USTUR, Washington State University, 1845 Terminal Dr. Suite 201, Richland, WA 99354-4959 USA, 1-509-946-6870 or 1-800-375-9317