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USTUR 0269: Hanford — 1956 Acute Inhalation — Soluble 239Pu — Chelated
Intake
1956: This whole body donation case involved a single acute inhalation of an acidic Pu(NO3)4 solution in the form of an aerosol ‘mist.’
Chelation
Chelation treatment with i.v. Ca-EDTA was initiated on the day of the intake, and continued intermittently over 6 months. After 2½ years with no further treatment, a course of i.v. Ca-DTPA was administered.
Health Physics
Chelation treatment with i.v. Ca-EDTA was initiated on the day of the intake, and continued intermittently over 6 months. After 2½ years with no further treatment, a course of i.v. Ca-DTPA was administered. A total of 400 measurements of 239+240Pu excreted in urine were recorded; starting on the first day (both before and during the initial Ca-EDTA chelation), and continuing for 37 years. This sampling included all intervals of chelation. In addition, 91 measurements of 239+240Pu-in-feces were recorded over this whole period.
Autopsy and Pathology
The Registrant died about 38 years after the intake, at age 79 y, with extensive carcinomatosis secondary to adenocarcinoma of the prostate gland. At autopsy, all major soft tissue organs were harvested for radiochemical analyses of their 238Pu, 239+240Pu and 241Am content. Also, all types of bone (comprising about half the skeleton) were harvested for radiochemical analyses, as well as samples of skin, subcutaneous fat and muscle.
Biokinetic Modeling
This comprehensive dataset has been applied to derive ‘chelation-enhanced’ transfer rates in the ICRP Publication 67 plutonium biokinetic model, representing the behavior of blood-borne and tissue-incorporated plutonium during intervals of therapy. The resulting model of the separate effects of i.v. Ca- EDTA and Ca-DTPA chelation shows that the therapy administered in this case succeeded in reducing substantially the long-term burden of plutonium in all body organs, except for the lungs. The calculated reductions in organ content at the time of death are approximately 40% for the liver, 60% for other soft tissues (muscle, skin, glands, etc.), 50% for the kidneys, and 50% for the skeleton. Essentially all of the substantial reduction in skeletal burden occurred in trabecular bone. This modeling exercise demonstrated that 3-y-delayed Ca-DTPA therapy was as effective as promptly administered Ca-EDTA.
Related Links
James, A. C., Sasser, L. B., Stuit, D. B., Glover, S. E., Carbaugh, E. H. USTUR Whole Body Case 0269: Demonstrating Effectiveness of i.v. Ca-DTPA for Pu. Radiation Protection Dosimetry (2007). 127: 449-455.
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Keywords: Hanford, inhalation, acute, 239Pu(NO3)4, soluble Pu, chelation, Ca-EDTA, Ca-DTPA
To use USTUR narrative data, please cite:
USTUR 0269: Hanford — 1956 Acute Inhalation — Soluble 239Pu — Chelated: Narrative. United States Transuranium and Uranium Registries. 14 May 2009. Washington State University: College of Pharmacy. Accessed 23 November 2009. Available at: http://www.ustur.wsu.edu/Case_Studies/Narratives/0269_Narrative.php.
This page was last updated on May 14, 2009. usturwebmaster@tricity.wsu.edu
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